The first three serotypes
In 1922 Vallée and Carré demonstrated that there were two serotypes of FMDV (Vallée & Carré, 1922). They named these Vallée O and Vallée A, after the regions they orginated from (department of Oise in France and Germany [Allemagne in French]).
Four years later Waldmann and Trautwein demonstrated the existance of three serotypes (Waldmann & Trautwein, 1926). Which they named Waldmann A, B and C. Waldmann A and Waldmann B were found to be the same as Vallée O and Vallée A, respectively. While Waldmann C remained as a distinct third serotype.
The names of Vallée O, Vallée A and Waldmann C were later shortened to O, A and C.
The next three serotypes
Two new serotypes were identified in 1948 in samples from Bechuanaland (Botswana) and Northern Rhodesia (Zambia) (Brooksby, 1958). Retrospective testing of samples from Southern Rhodesia (Zimbabwe) from the 1930s found both of these new serotypes and a third new serotype as well.
These new serotypes were named Southern African Territories 1 to 3 (abreviated to SAT 1, SAT 2 and SAT 3).
The final serotype
The serotype Asia 1 was identified in the early 1950s in viruses isolated from India and Pakistan (Dhanda et al., 1957 and Brooksby & Rogers, 1957).
The WRLFMD uses a standard colour scheme for serotypes:
SAT 1: Yellow
SAT 2: Purple
SAT 3: Orange
Genetics of the serotypes
Each serotype can be genetically split into various topotypes and lineages.Topotypes and lineages
When writing down the combination of serotype, topotype and lineage of a strain of foot-and-mouth disease virus the WRLFMD suggests the following format:
The serotype, abbreviated topotype and lineage in this order, each seperated by a forward slash (/). If there is a sub-lineage it is appended to the Lineage as a superscript:
SEROTYPE /TOPOTYPE ABBREVIATION/LineageSUB-LINEAGE
(for example: O/ME-SA/PanAsia-2TER-08, A/ASIA/Iran-05HER-10, Asia 1/ASIA/Sindh-08, etc.)
Genetic relationship (using VP1 sequences) between FMDV serotypes. The prototype strain sequences used to create this phylogenetic tree are available on this site